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KMID : 0903520090520050493
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Journal of the Korean Society of Agricultural Chemistry and Biotechnology
2009 Volume.52 No. 5 p.493 ~ p.497
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Aldose Reductase Inhibitors from the Leaves of Salix hulteni
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Park Hyun-Young
Kim Hye-Kyung
Jeon Seong-Ho
Kim Soo-Hee
Chun Wan-Joo
Lim Soon-Sung
Kim Myong-Jo
Kwon Yong-Soo
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Abstract
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From the n-BuOH soluble fraction of the leaves of Salix hulteni, six compounds were isolated as aldose reductase inhibitors. On the basis of spectral data, these compounds were identified as diosmetin-7-O-β-D-glucoside (1), isoquercitrin (2), diosmetin-7-O-β-D-xylosyl-(1→6)-β-D-glucoside (3), aromadendrin-3-O-β-D-glucoside (4), astragalin (5), and p-hydroxyacetophenone glucoside (6). All of the isolates were evaluated in vitro for inhibitory activity against the aldose reductase. Of these, compounds 1-5 exhibited inhibitory activity against aldose reductase with IC50 values ranging 1.4 to 5.8 μM.
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KEYWORD
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diabetic complications, flavonoids, human aldose reductase, inhibitory activity, leaves, Salix hulteni
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